Article
Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality.
The EMBO journal - 2 Oct 2000
Hesse M, Franz T, Tamai Y, Taketo M M, Magin T M
Abstract excerpt
It has been reported previously that keratin 8 (K8)-deficient mice of one strain die from a liver defect at around E12.5, while those of another strain suffer from colorectal hyperplasia. These findings have generated considerable confusion about the function of K8, K18 and K19 that are co-expressed in the mouse blastocyst and internal epithelia. To resolve this issue, we produced mice doubly deficient for K18...
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