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Article

A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice.

Experimental cell research - 15 Aug 2007

Hesse Michael, Grund Christine, Herrmann Harald, Bröhl Dominique, Franz Thomas, Omary M Bishr, Magin Thomas M

Abstract excerpt

Mutations in genes encoding epidermal keratins cause skin disorders, while those in internal epithelial keratins, such as K8 and K18, are risk factors for liver diseases. The effect of dominant mutations in K8 or K18 during embryonic development and tissue homeostasis has not been examined so far...

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Identifiers

PMID: 17617404
DOI: 10.1016/j.yexcr.2007.05.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17617404-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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