Article
HLA-DP4, the most frequent HLA II molecule, defines a new supertype of peptide-binding specificity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2002
Castelli Florence A, Buhot Cécile, Sanson Alain, Zarour Hassane, Pouvelle-Moratille Sandra, Nonn Céline, Gahery-Ségard Hanne, Guillet Jean-Gérard, Ménez André, Georges Bertrand, Maillère Bernard
Abstract excerpt
Among HLA-DP specificities, HLA-DP4 specificity involves at least two molecules, HLA-DPA1*0103/DPB1*0401 (DP401) and HLA-DPA1*0103/DPB1*0402 (DP402), which differ from each other by only three residues. Together, they are present worldwide at an allelic frequency of 20-60% and are the most abundant human HLA II alleles. Strikingly, the peptide-binding specificities of these molecules have never been investigated....
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Amino Acid Substitution
- Cell Line
- Epitopes
- Gene Frequency
- HLA-DP Antigens
- HLA-DP beta-Chains
- Histocompatibility Testing
- Humans
- Models, Molecular
- Molecular Sequence Data