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Article

HLA-DP4, the most frequent HLA II molecule, defines a new supertype of peptide-binding specificity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2002

Castelli Florence A, Buhot Cécile, Sanson Alain, Zarour Hassane, Pouvelle-Moratille Sandra, Nonn Céline, Gahery-Ségard Hanne, Guillet Jean-Gérard, Ménez André, Georges Bertrand, Maillère Bernard

Abstract excerpt

Among HLA-DP specificities, HLA-DP4 specificity involves at least two molecules, HLA-DPA1*0103/DPB1*0401 (DP401) and HLA-DPA1*0103/DPB1*0402 (DP402), which differ from each other by only three residues. Together, they are present worldwide at an allelic frequency of 20-60% and are the most abundant human HLA II alleles. Strikingly, the peptide-binding specificities of these molecules have never been investigated....

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Identifiers

PMID: 12471126
DOI: 10.4049/jimmunol.169.12.6928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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