Mechanism of interferon action. Translational control and the RNA-dependent protein kinase (PKR): antagonists of PKR enhance the translational activity of mRNAs that include a 161 nucleotide region from reovirus S1 mRNA.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Mechanism of interferon action. Translational control and the RNA-dependent protein kinase (PKR): antagonists of PKR enhance the translational activity of mRNAs that include a 161 nucleotide region from reovirus S1 mRNA.

Journal of biological regulators and homeostatic agents - 1 Jan 2000

Henry G L, McCormack S J, Thomis D C, Samuel C E

Abstract excerpt

The interferon-inducible, RNA-dependent protein kinase (PKR) is an important regulator of viral protein synthesis. Activated PKR inhibits protein synthesis by phosphorylating initiation factor eIF-2 alpha. The reovirus S4 gene, whose 1196 nucleotide mRNA transcript does not activate the PKR kinase, is efficiently expressed in vector-transfected monkey COS cells. By contrast, the 1463 nucleotide S1 gene of...

Topics

2-Aminopurine
Animals
Binding Sites
Cell Line
Enzyme Activation
Gene Expression Regulation, Viral
Genes, Viral
Genetic Vectors
Interferons
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Protein Biosynthesis

Protein Serine-Threonine Kinases

RNA, Messenger

RNA, Viral

Retroviridae

Transfection

eIF-2 Kinase

Source

Open in PubMed

Identifiers

PMID: 7526609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7526609-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of interferon action. Translational control and the RNA-dependent protein kinase (PKR): antagonists of PKR enhance the translational activity of mRNAs that include a 161 nucleotide region from reovirus S1 mRNA.PMID 7526609Read ↗

Involvement of the Interferon-Regulated Antiviral Proteins PKR and RNase L in Reovirus-Induced Shutoff of Cellular TranslationSemantic proximity Read ↗

The reovirus S4 gene 3' nontranslated region contains a translational operator sequence.Semantic proximity Read ↗

Mechanism of interferon action: evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR.Semantic proximity Read ↗

Mechanism of interferon action. Biochemical and genetic evidence for the intermolecular association of the RNA-dependent protein kinase PKR from human cells.Semantic proximity Read ↗

Paramyxovirus-Induced Shutoff of Host and Viral Protein Synthesis: Role of the P and V Proteins in Limiting PKR ActivationSemantic proximity Read ↗

Autogenous Translational Regulation of the Borna Disease Virus Negative Control Factor X from Polycistronic mRNA Using Host RNA HelicasesSemantic proximity Read ↗

PKR-Dependent Mechanisms of Gene Expression from a Subgenomic Hepatitis C Virus CloneSemantic proximity Read ↗

Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.Semantic proximity Read ↗

The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.Semantic proximity Read ↗

TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.Semantic proximity Read ↗

Sendai Virus and Simian Virus 5 Block Activation of Interferon-Responsive Genes: Importance for Virus PathogenesisSemantic proximity Read ↗

Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.