Article
Mechanism of interferon action. Translational control and the RNA-dependent protein kinase (PKR): antagonists of PKR enhance the translational activity of mRNAs that include a 161 nucleotide region from reovirus S1 mRNA.
Journal of biological regulators and homeostatic agents - 1 Jan 2000
Henry G L, McCormack S J, Thomis D C, Samuel C E
Abstract excerpt
The interferon-inducible, RNA-dependent protein kinase (PKR) is an important regulator of viral protein synthesis. Activated PKR inhibits protein synthesis by phosphorylating initiation factor eIF-2 alpha. The reovirus S4 gene, whose 1196 nucleotide mRNA transcript does not activate the PKR kinase, is efficiently expressed in vector-transfected monkey COS cells. By contrast, the 1463 nucleotide S1 gene of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.