Article
The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection.
Journal of virology - 1 Oct 2009
Spurgeon Megan E, Ornelles David A
Abstract excerpt
During a productive infection, species C adenovirus reprograms the host cell to promote viral translation at the expense of cellular translation. The E1B 55-kilodalton (E1B-55K) and E4 open reading frame 6 (E4orf6) proteins are important in this control of gene expression. As part of a ubiquitin-protein ligase, these viral proteins stimulate viral mRNA export, inhibit cellular mRNA export, promote viral gene...
Topics
- Adenoviridae
- Adenoviridae Infections
- Adenovirus E1B Proteins
- Cytoplasm
- Eukaryotic Initiation Factor-2
- HeLa Cells
- Humans
- Models, Biological
- Mutation
- Open Reading Frames
- Phosphorylation
- Reoviridae
- Reverse Transcriptase Polymerase Chain Reaction
- Subcellular Fractions
- eIF-2 Kinase