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Article

Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.

Journal of virology - 1 Jan 1995

Beattie E, Denzler K L, Tartaglia J, Perkus M E, Paoletti E, Jacobs B L

Abstract excerpt

The vaccinia virus (VV) E3L gene, which encodes a potent inhibitor of the interferon (IFN)-induced, double-stranded RNA (dsRNA)-dependent protein kinase, PKR, is thought to be involved in the IFN-resistant phenotype of VV. The E3L gene products, p25 and p20, act as inhibitors of PKR, presumably b...

Topics

Animals
Base Sequence
Chlorocebus aethiops
Gene Expression
Genes, Viral
Interferons
Molecular Sequence Data
Phenotype
Protein Serine-Threonine Kinases
RNA, Viral
RNA-Binding Proteins
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reoviridae

Vaccinia virus

Vero Cells

Viral Proteins

eIF-2 Kinase

Source

Open in PubMed Open full text

Identifiers

PMID: 7527085
DOI: 10.1128/JVI.69.1.499-505.1995
PMCID: PMC188598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7527085-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.PMID 7527085Read ↗

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