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Article

Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.

Journal of virology - 1 Jan 1995

Beattie E, Denzler K L, Tartaglia J, Perkus M E, Paoletti E, Jacobs B L

Abstract excerpt

The vaccinia virus (VV) E3L gene, which encodes a potent inhibitor of the interferon (IFN)-induced, double-stranded RNA (dsRNA)-dependent protein kinase, PKR, is thought to be involved in the IFN-resistant phenotype of VV. The E3L gene products, p25 and p20, act as inhibitors of PKR, presumably by binding and sequestering activator dsRNA from the kinase. In this study we demonstrate that VV with the E3L gene...

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Identifiers

PMID: 7527085
DOI: 10.1128/JVI.69.1.499-505.1995
PMCID: PMC188598

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