TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.

doi:10.1073/pnas.91.11.4713

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Article

TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 1994

Park H, Davies M V, Langland J O, Chang H W, Nam Y S, Tartaglia J, Paoletti E, Jacobs B L, Kaufman R J, Venkatesan S

Abstract excerpt

A cDNA encoding a double-stranded-RNA (dsRNA)-binding protein was isolated by screening a HeLa cell cDNA expression library for proteins that bind the HIV-1 Rev-responsive-element RNA. The cDNA encoded a protein that was identical to TRBP, the previously reported cellular protein that binds the t...

Topics

Animals
Bacterial Proteins
Cell Line
Chemoreceptor Cells
Enzyme Induction
Escherichia coli Proteins
Eukaryotic Initiation Factor-2
Genetic Complementation Test
HeLa Cells
Humans
Interferons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Phenotype

Phosphorylation

Protein Serine-Threonine Kinases

RNA-Binding Proteins

Receptors, Cell Surface

Vaccinia virus

Source

Open in PubMed Open full text

Identifiers

PMID: 7515177
DOI: 10.1073/pnas.91.11.4713
PMCID: PMC43858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7515177-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.PMID 7515177Read ↗

The TAR RNA-binding protein, TRBP, stimulates the expression of TAR-containing RNAs in vitro and in vivo independently of its ability to inhibit the dsRNA-dependent kinase PKR.Semantic proximity Read ↗

The Cellular TAR RNA Binding Protein, TRBP, Promotes HIV-1 Replication Primarily by Inhibiting the Activation of Double-Stranded RNA-Dependent Kinase PKRSemantic proximity Read ↗

Two dimerization domains in the trans-activation response RNA-binding protein (TRBP) individually reverse the protein kinase R inhibition of HIV-1 long terminal repeat expression.Semantic proximity Read ↗

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HIV-1 TAR RNA Subverts RNA Interference in Transfected Cells through Sequestration of TAR RNA-binding Protein, TRBPSemantic proximity Read ↗

The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR).Semantic proximity Read ↗

Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTRSemantic proximity Read ↗

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Dominant Negative Function by an Alternatively Spliced Form of the Interferon-inducible Protein Kinase PKRSemantic proximity Read ↗

The VP35 protein of Ebola virus inhibits the antiviral effect mediated by double-stranded RNA-dependent protein kinase PKR.Semantic proximity Read ↗

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