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Article

TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 1994

Park H, Davies M V, Langland J O, Chang H W, Nam Y S, Tartaglia J, Paoletti E, Jacobs B L, Kaufman R J, Venkatesan S

Abstract excerpt

A cDNA encoding a double-stranded-RNA (dsRNA)-binding protein was isolated by screening a HeLa cell cDNA expression library for proteins that bind the HIV-1 Rev-responsive-element RNA. The cDNA encoded a protein that was identical to TRBP, the previously reported cellular protein that binds the transactivation response element (TAR) RNA of human immunodeficiency virus type 1. TRBP inhibited phosphorylation of the...

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Identifiers

PMID: 7515177
DOI: 10.1073/pnas.91.11.4713
PMCID: PMC43858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.PMID 7515177Read ↗

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The Cellular TAR RNA Binding Protein, TRBP, Promotes HIV-1 Replication Primarily by Inhibiting the Activation of Double-Stranded RNA-Dependent Kinase PKRSemantic proximity Read ↗

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