Article
MUTYH-associated polyposis (MAP).
Critical reviews in oncology/hematology - 1 Jul 2011
Nielsen Maartje, Morreau Hans, Vasen Hans F A, Hes Frederik J
Abstract excerpt
The human mutY homologue (MUTYH) gene is responsible for inheritable polyposis and colorectal cancer. This review discusses the molecular genetic aspects of the MUTYH gene and protein, the clinical impact of mono- and biallelic MUTYH mutations and histological aspects of the MUTYH tumors. Furthermore, the relationship between MUTYH and the mismatch repair genes in colorectal cancer (CRC) families is examined....
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