Article
Hereditary non-polyposis colorectal cancer: clinical and molecular evidence for a new entity of hereditary colorectal cancer.
Gut - 1 Dec 2005
Mueller-Koch Y, Vogelsang H, Kopp R, Lohse P, Keller G, Aust D, Muders M, Gross M, Daum J, Schiemann U, Grabowski M, Scholz M, Kerker B, Becker I, Henke G, Holinski-Feder E
Abstract excerpt
BACKGROUND: Hereditary non-polyposis colorectal cancer (HNPCC) is clinically defined by familial clustering of colorectal cancer and other associated tumours. METHODS: By thorough molecular and clinical evaluation of 41 families, two different groups were characterised: group 1, 25 families with truncating mutations in MLH1 or MSH2 (12 novel mutations); and group 2, 16 Amsterdam positive families without...
Topics
- Adaptor Proteins, Signal Transducing
- Adult
- Age of Onset
- Carrier Proteins
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Disease Progression
- Female
- Humans
- Male
- Microsatellite Repeats