Article
Disruption of the Saccharomyces cerevisiae cell-wall pathway gene SLG1 causes hypersensitivity to the antitumor drug bleomycin.
Molecular genetics and genomics : MGG - 1 Apr 2003
Leduc A, He C H, Ramotar D
Abstract excerpt
Bleomycin is an antitumor drug that damages DNA via a free radical-dependent mechanism, and yeast mutants defective in DNA repair are hypersensitive to the drug. To identify possible pathways that may contribute to bleomycin resistance in yeast, we characterized a panel of bleomycin-sensitive mutants that were previously isolated by insertion mutagenesis using the transposon miniTn3::Leu2::LacZ::AMP( R). One of...
Topics
- Antibiotics, Antineoplastic
- Bleomycin
- Cell Wall
- DNA Damage
- Drug Resistance, Fungal
- Genes, Fungal
- Mutation
- Saccharomyces cerevisiae