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Article

Single-nucleotide sequence discrimination in situ using padlock probes.

Current protocols in cytometry - 1 May 2001

Nilsson M, Landegren U, Antson D O

Abstract excerpt

Standard fluorescence in situ hybridization (FISH) techniques using cloned probes are limited in their ability to distinguish between closely similar DNA sequences because long hybridization probes are not detectably destabilized by single mismatched base pairs. This problem has been addressed by using short allele-specific oligonucleotide probes whose hybridization to target sequences is more sensitive to...

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PMID: 18770746
DOI: 10.1002/0471142956.cy0808s16

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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