Article
Molecular analysis of PDGFRA and PDGFRB genes by rapid single-strand conformation polymorphism (SSCP) in patients with core-binding factor leukaemias with KIT or FLT3 mutation.
Anticancer research - 1 Jan 2000
Trojani Alessandra, Ripamonti Carla Barbara, Penco Silvana, Beghini Alessandro, Nadali Gianpaolo, Di Bona Eros, Viola Assunta, Castagnola Carlo, Colapietro Patrizia, Grillo Giovanni, Pezzetti Laura, Ravelli Erica, Patrosso Maria Cristina, Marocchi Alessandro, Cuneo Antonio, Ferrara Felicetto, Lazzarino Mario, Pizzolo Giovanni, Cairoli Roberto, Morra Enrica
Abstract excerpt
BACKGROUND: Mutations involving KIT and FLT3 genes, encoding tyrosine kinase (TK) membrane receptors, are detected in core-binding factor leukaemia (CBFL) patients. PDFGRA and PDGFRB encode class III TK receptors and are involved both in physiological processes and in the pathogenesis of haematol...
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