Article
No evidence for GM-CSF receptor alpha chain gene mutation in AML-M2 leukemias which have lost a sex chromosome.
Leukemia - 1 Oct 1994
Brown M A, Harrison-Smith M, DeLuca E, Begley C G, Gough N M
Abstract excerpt
Sixty-five percent of acute myeloid leukemias subtype M2 (AML-M2), displaying a translocation between chromosomes 8 and 21 (t8;21) have also lost one or other copy of the sex chromosomes (XO). This finding has led to the hypothesis that a recessive oncogene may be present in the DNA common to bot...
Topics
- Base Sequence
- Blotting, Northern
- Chromosome Deletion
- DNA Mutational Analysis
- Humans
- Leukemia, Myeloid, Acute
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
- Sex Chromosomes