Article
Analysis of c-kit gene integrity in aplastic anemia.
Blood cells, molecules & diseases - 1 Jan 1996
Paquette R L, Hsu N C, Koeffler H P
Abstract excerpt
Mice harboring the "white spotting" (W) locus have abnormalities in hematopoiesis due to one of various mutations of the c-kit proto-oncogene, which encodes the stem cell factor (SCF) receptor. The c-kit mutations identified in W mice cause diminished, absent or dominant negative receptor function. This study explores the hypothesis that acquired mutations of c-kit in the hematopoietic stem cell participate in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
