Analysis of c-kit gene integrity in aplastic anemia.

doi:10.1006/bcmd.1996.0023

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Article

Analysis of c-kit gene integrity in aplastic anemia.

Blood cells, molecules & diseases - 1 Jan 1996

Paquette R L, Hsu N C, Koeffler H P

Abstract excerpt

Mice harboring the "white spotting" (W) locus have abnormalities in hematopoiesis due to one of various mutations of the c-kit proto-oncogene, which encodes the stem cell factor (SCF) receptor. The c-kit mutations identified in W mice cause diminished, absent or dominant negative receptor functio...

Topics

Adult
Aged
Anemia, Aplastic
Animals
Female
Humans
Male
Mice
Middle Aged
Mutation
Polymerase Chain Reaction
Proto-Oncogene Mas
Proto-Oncogene Proteins c-kit

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