Article
Molecular analysis of the IL-6 receptor in human multiple myeloma, an IL-6-related disease.
FEBS letters - 21 Mar 1994
Rodriguez C, Theillet C, Portier M, Bataille R, Klein B
Abstract excerpt
A PCR-SSCP approach was used to search for mutations in IL-6 receptor genes in 9 human plasma cell lines (HMCL) and in tumor plasma cells from 19 patients with fulminating multiple myeloma, an IL-6-related disease. Whereas no mutation was found in the cytokine receptor homologous (CRH) domain of...
Topics
- Antigens, CD
- Base Sequence
- Cytokine Receptor gp130
- Cytoplasm
- DNA Primers
- DNA, Neoplasm
- Humans
- Interleukin-6
- Membrane Glycoproteins
- Molecular Sequence Data
- Multiple Myeloma
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptors, Interleukin
- Receptors, Interleukin-6
- Tumor Cells, Cultured