Article
Regulatory rearrangements and smg-sensitive alleles of the C. elegans sex-determining gene tra-1.
Developmental genetics - 1 Jan 1994
Zarkower D, De Bono M, Aronoff R, Hodgkin J
Abstract excerpt
The tra-1 gene is the terminal regulator in the sex determination pathway in C. elegans, directing all aspects of somatic sexual differentiation. Recessive loss-of-function (lf) mutations in tra-1 masculinize XX animals (normally somatically female), while dominant gain-of-function mutations feminize XO animals (normally male). Most tra-1 (lf) mutations can be fitted into a simple allelic series of somatic...
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