Article
xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor TRA-1.
Development (Cambridge, England) - 1 Dec 2009
Hargitai Balázs, Kutnyánszky Vera, Blauwkamp Timothy A, Steták Attila, Csankovszki Györgyi, Takács-Vellai Krisztina, Vellai Tibor
Abstract excerpt
In the nematode Caenorhabditis elegans, sex is determined by the ratio of X chromosomes to sets of autosomes: XX animals (2X:2A=1.0) develop as hermaphrodites and XO animals (1X:2A=0.5) develop as males. TRA-1, the worm ortholog of Drosophila Cubitus interruptus and mammalian Gli (Glioma-associated homolog) proteins, is the terminal transcription factor of the C. elegans sex-determination pathway, which specifies...
Topics
- Animals
- Base Sequence
- Binding Sites
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Consensus Sequence
- Conserved Sequence
- DNA-Binding Proteins
- Dosage Compensation, Genetic
- Genes, Helminth
- Genes, Switch
- Genes, X-Linked