Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor TRA-1.

Development (Cambridge, England) - 1 Dec 2009

Hargitai Balázs, Kutnyánszky Vera, Blauwkamp Timothy A, Steták Attila, Csankovszki Györgyi, Takács-Vellai Krisztina, Vellai Tibor

Abstract excerpt

In the nematode Caenorhabditis elegans, sex is determined by the ratio of X chromosomes to sets of autosomes: XX animals (2X:2A=1.0) develop as hermaphrodites and XO animals (1X:2A=0.5) develop as males. TRA-1, the worm ortholog of Drosophila Cubitus interruptus and mammalian Gli (Glioma-associated homolog) proteins, is the terminal transcription factor of the C. elegans sex-determination pathway, which specifies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Consensus Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dosage Compensation, Genetic

Share to Genes, Helminth

Share to Genes, Switch

Share to Genes, X-Linked

Share to Sex Determination Processes

Share to X Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 19906855
DOI: 10.1242/dev.034637
PMCID: PMC2778738

Genes

TRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor TRA-1.PMID 19906855Read ↗

Sex Determination: TRA-1 Is a Non-binary Regulator of Sexual Identity.Semantic proximity Read ↗

The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex.Semantic proximity Read ↗

RNA-Regulated TRA-1 nuclear export controls sexual fate.Semantic proximity Read ↗

The tra-1 gene determines sexual phenotype cell-autonomously in C. elegans.Semantic proximity Read ↗

Dominant feminizing mutations implicate protein-protein interactions as the main mode of regulation of the nematode sex-determining gene tra-1.Semantic proximity Read ↗

Sex-specific regulation of neuronal functions in Caenorhabditis elegans: the sex-determining protein TRA-1 represses goa-1/Gα(i/o).Semantic proximity Read ↗

Conservation of the global sex determination gene tra-1 in distantly related nematodes.Semantic proximity Read ↗

Somatic sex determinationSemantic proximity Read ↗

The C. elegans Sex-Determining GLI Protein TRA-1A Is Regulated by Sex-Specific ProteolysisSemantic proximity Read ↗

A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination.Semantic proximity Read ↗

The primary sex determination signal of Caenorhabditis elegans.Semantic proximity Read ↗

The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.