Article
Dominant feminizing mutations implicate protein-protein interactions as the main mode of regulation of the nematode sex-determining gene tra-1.
Genes & development - 15 Jan 1995
de Bono M, Zarkower D, Hodgkin J
Abstract excerpt
The tra-1 gene is the terminal global selector of somatic sex in Caenorhabditis elegans: High tra-1 activity elicits female somatic development while low tra-1 activity elicits male development. Previous genetic studies defined a cascade of negatively interacting genes that regulates tra-1 activi...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- DNA-Binding Proteins
- Down-Regulation
- Female
- Gene Expression Regulation, Developmental
- Genes, Helminth
- Helminth Proteins
- Male
- Membrane Proteins
- Models, Genetic
- Molecular Sequence Data
- Phenotype
- Point Mutation