No TP53 mutations in neuroblastomas detected by PCR-SSCP analysis.

doi:10.1002/gcc.2870100209

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Article

No TP53 mutations in neuroblastomas detected by PCR-SSCP analysis.

Genes, chromosomes & cancer - 1 Jun 1994

Castresana J S, Bello M J, Rey J A, Nebreda P, Queizán A, García-Miguel P, Pestaña A

Abstract excerpt

We have analysed 29 neuroblastomas for TP53 mutations in exons 5 to 8 by means of the polymerase chain reaction in combination with the single-strand conformation polymorphism technique. We could not detect any mutation. These results indicate that, in contrast to the majority of tumors so far st...

Topics

DNA, Neoplasm
DNA, Single-Stranded
Exons
Genes, p53
Humans
Mutation
Neuroblastoma
Polymerase Chain Reaction
Polymorphism, Genetic

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