Lack of mutations in the P53 gene exons 5 to 8 in ataxia-telangiectasia.

doi:10.1016/0165-4608(93)90242-e

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Article

Lack of mutations in the P53 gene exons 5 to 8 in ataxia-telangiectasia.

Cancer genetics and cytogenetics - 1 Apr 1993

Jonveaux P, Berger R

Abstract excerpt

Alterations of the TP53 tumor suppressor gene are present in various human malignancies and in the dominantly inherited Li-Fraumeni syndrome. Recently, a cell cycle checkpoint pathway involving p53 and GADD45 has been identified as defective in ataxia-telangiectasia. Using single strand conformat...

Topics

Ataxia Telangiectasia
Base Sequence
Exons
Genes, p53
Humans
Molecular Sequence Data
Mutation

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