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Article

The murine steel panda mutation affects kit ligand expression and growth of early ovarian follicles.

Developmental biology - 1 May 1993

Huang E J, Manova K, Packer A I, Sanchez S, Bachvarova R F, Besmer P

Abstract excerpt

Mutations at the murine steel (Sl) locus encoding the ligand for the c-kit receptor result in defects in gametogenesis, hematopoiesis, and melanogenesis. Steel Panda (Slpan) is an allele at the Sl locus obtained by an X-ray mutagenesis protocol. Slpan/Slpan homozygotes are mildly anemic black-eyed whites with pigmented ears and scrotum; females are sterile while males are fertile. To investigate the basis of the...

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PMID: 7683280
DOI: 10.1006/dbio.1993.1115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The murine steel panda mutation affects kit ligand expression and growth of early ovarian follicles.PMID 7683280Read ↗

DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development.Semantic proximity Read ↗

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.Semantic proximity Read ↗

The murine W/c-kit and Steel loci and the control of hematopoiesis.Semantic proximity Read ↗

The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor.Semantic proximity Read ↗

W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.Semantic proximity Read ↗

Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci.Semantic proximity Read ↗

A mutation in the Kit gene leads to novel gonadal phenotypes in both heterozygous and homozygous mice.Semantic proximity Read ↗

Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.Semantic proximity Read ↗

Effects of spontaneous KitlSteel mutations on survival and red blood cells of mice.Semantic proximity Read ↗

Identification of <i>kit-ligand a</i> as the Gene Responsible for the Medaka Pigment Cell Mutant <i>few melanophore</i>Semantic proximity Read ↗

Identification of kit-ligand a as the Gene Responsible for the Medaka Pigment Cell Mutant few melanophore.Semantic proximity Read ↗

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