The murine steel panda mutation affects kit ligand expression and growth of early ovarian follicles.

doi:10.1006/dbio.1993.1115

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Article

The murine steel panda mutation affects kit ligand expression and growth of early ovarian follicles.

Developmental biology - 1 May 1993

Huang E J, Manova K, Packer A I, Sanchez S, Bachvarova R F, Besmer P

Abstract excerpt

Mutations at the murine steel (Sl) locus encoding the ligand for the c-kit receptor result in defects in gametogenesis, hematopoiesis, and melanogenesis. Steel Panda (Slpan) is an allele at the Sl locus obtained by an X-ray mutagenesis protocol. Slpan/Slpan homozygotes are mildly anemic black-eyed whites with pigmented ears and scrotum; females are sterile while males are fertile. To investigate the basis of the...

Topics

Aging
Alleles
Animals
Base Sequence
Brain
Crosses, Genetic
Female
Gene Expression
Hematopoietic Cell Growth Factors
Homozygote
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C3H

Mice, Inbred C57BL

Mice, Inbred ICR

Mice, Inbred Strains

Molecular Sequence Data

Mutagenesis

Source

Open in PubMed

Identifiers

PMID: 7683280
DOI: 10.1006/dbio.1993.1115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7683280-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The murine steel panda mutation affects kit ligand expression and growth of early ovarian follicles.PMID 7683280Read ↗

DNA rearrangements located over 100 kb 5' of the Steel (Sl)-coding region in Steel-panda and Steel-contrasted mice deregulate Sl expression and cause female sterility by disrupting ovarian follicle development.Semantic proximity Read ↗

The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis.Semantic proximity Read ↗

A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.Semantic proximity Read ↗

The murine W/c-kit and Steel loci and the control of hematopoiesis.Semantic proximity Read ↗

The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor.Semantic proximity Read ↗

W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.Semantic proximity Read ↗

Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci.Semantic proximity Read ↗

A mutation in the Kit gene leads to novel gonadal phenotypes in both heterozygous and homozygous mice.Semantic proximity Read ↗

Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.Semantic proximity Read ↗

Effects of spontaneous KitlSteel mutations on survival and red blood cells of mice.Semantic proximity Read ↗

Identification of <i>kit-ligand a</i> as the Gene Responsible for the Medaka Pigment Cell Mutant <i>few melanophore</i>Semantic proximity Read ↗

Identification of kit-ligand a as the Gene Responsible for the Medaka Pigment Cell Mutant few melanophore.Semantic proximity Read ↗

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