Article
Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: humoral immune response to hypervariable region 1.
International journal of cancer - 1 Jun 1994
Sekiya H, Kato N, Ootsuyama Y, Nakazawa T, Yamauchi K, Shimotohno K
Abstract excerpt
Hypervariable region I (HVRI) of the putative second envelope glycoprotein (gp70) of hepatitis C virus (HCV) undergoes sequential alterations at intervals of several months during the chronic phase of hepatitis. To evaluate the implications of sequence variability in HVRI of HCV, we investigated the sequence variability of the whole envelope-protein(gp35 and gp70)-coding regions of HCV genome derived from patient...
Topics
- Adult
- Amino Acid Sequence
- Base Sequence
- DNA Primers
- Epitopes
- Hepacivirus
- Hepatitis Antibodies
- Hepatitis C
- Humans
- Male
- Molecular Sequence Data