Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ontogeny of hepatitis C virus (HCV) hypervariable region 1 (HVR1) heterogeneity and HVR1 antibody responses over a 3 year period in a patient infected with HCV type 2b.

The Journal of general virology - 1 Feb 1999

Majid A, Jackson P, Lawal Z, Pearson G M, Parker H, Alexander G J, Allain J P, Petrik J

Abstract excerpt

Hypervariable region 1 (HVR1) sequences of 96 clones at six time-points representing 27 variants in two major and one minor group were identified in a patient with chronic hepatitis C virus (HCV) infection over 3 years. Major and selected minor variants were used to design synthetic peptides corresponding to the HVR1 C terminus. Peptide ELISA reactivity with IgG was plotted against the corresponding clone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross Reactions
Share to Gene Products, env

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, env

Share to Hepacivirus

Share to Hepatitis C Antibodies

Share to Hepatitis C, Chronic

Share to Interferon Type I

Share to Recombinant Proteins

Source

Identifiers

PMID: 10073690
DOI: 10.1099/0022-1317-80-2-317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ontogeny of hepatitis C virus (HCV) hypervariable region 1 (HVR1) heterogeneity and HVR1 antibody responses over a 3 year period in a patient infected with HCV type 2b.PMID 10073690Read ↗

Hypervariable region diversity of hepatitis C virus and humoral response: comparison between patients with or without cirrhosis.Semantic proximity Read ↗

Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants.Semantic proximity Read ↗

A possible role of hypervariable region 1 quasispecies in escape of hepatitis C virus particles from neutralization.Semantic proximity Read ↗

A correlation between the heterogeneity of hypervariable region 1 of E2 glycoprotein of Hepatitis C virus (HCV) and HCV antibody profile: a case study.Semantic proximity Read ↗

Dynamics of hypervariable region 1 variation in hepatitis C virus infection and correlation with clinical and virological features of liver disease.Semantic proximity Read ↗

Genetic complexity and serum reactivity of HVR1 quasispecies of hepatitis C virus in patients with cirrhosis.Semantic proximity Read ↗

Changes in hypervariable region 1 of the envelope 2 glycoprotein of hepatitis C virus in children and adults with humoral immune defects.Semantic proximity Read ↗

Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV.Semantic proximity Read ↗

Genetic drift in hypervariable region 1 of the viral genome in persistent hepatitis C virus infection.Semantic proximity Read ↗

Prevalence of HCV HVR1 insertions and their role in antibody evasion.Semantic proximity Read ↗

A meta-analysis of the existing knowledge of immunoreactivity against hepatitis C virus (HCV).Semantic proximity Read ↗

High prevalence of hypervariable region 1-specific and -cross-reactive CD4(+) T cells in HCV-infected individuals responsive to IFN-alpha treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.