Article
Ontogeny of hepatitis C virus (HCV) hypervariable region 1 (HVR1) heterogeneity and HVR1 antibody responses over a 3 year period in a patient infected with HCV type 2b.
The Journal of general virology - 1 Feb 1999
Majid A, Jackson P, Lawal Z, Pearson G M, Parker H, Alexander G J, Allain J P, Petrik J
Abstract excerpt
Hypervariable region 1 (HVR1) sequences of 96 clones at six time-points representing 27 variants in two major and one minor group were identified in a patient with chronic hepatitis C virus (HCV) infection over 3 years. Major and selected minor variants were used to design synthetic peptides corresponding to the HVR1 C terminus. Peptide ELISA reactivity with IgG was plotted against the corresponding clone...
Topics
- Adult
- Amino Acid Sequence
- Amino Acid Substitution
- Cross Reactions
- Gene Products, env
- Genes, env
- Genetic Variation
- Hepacivirus
- Hepatitis C Antibodies
- Hepatitis C, Chronic