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Article

Drug-stimulated ATPase activity of a deletion mutant of the human multidrug-resistance protein (MDR1).

Biochemical and biophysical research communications - 13 Nov 1995

Welker E, Szabó K, Holló Z, Müller M, Sarkadi B, Váradi A

Abstract excerpt

The baculovirus-insect cell system has been used for the functional expression of the human multidrug resistance protein (MDR1) and a mutant MDR1 variant lacking a twenty amino acid segment from the first extracellular loop (delta aa78-97 MDR1). Both MDR1 proteins were found to be correctly inserted into the insect cell membrane as indicated by their interaction with MRK 16 antibody. The removal of the 78-97...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Adenosine Triphosphatases
Baculoviridae
Cell Membrane
Flow Cytometry
Genetic Variation
Genetic Vectors
Humans
Kinetics
Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Proteins

Sequence Deletion

Transfection

Source

Identifiers

PMID: 7488154
DOI: 10.1006/bbrc.1995.2665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7488154-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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