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Article

Functional Multidrug Resistance Protein (MRP1) Lacking the N-terminal Transmembrane Domain

1 Nov 1998

Abstract excerpt

The human multidrug resistance protein (MRP1) causes drug resistance by extruding drugs from tumor cells. In addition to an MDR-like core, MRP1 contains an N-terminal membrane-bound region (TMD0) connected to the core by a cytoplasmic linker (L0). We have studied truncated MRP1 versions containing either the MDR-like core alone or the core plus linker L0, produced in the baculovirus-insect (Sf9) cell system....

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Identifiers

PMID: 9822694
DOI: 10.1074/jbc.273.48.32167

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