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Article

Fluorescent verapamil derivative for monitoring activity of the multidrug transporter.

Molecular pharmacology - 1 Oct 1991

Lelong I H, Guzikowski A P, Haugland R P, Pastan I, Gottesman M M, Willingham M C

Abstract excerpt

Multidrug resistance to amphipathic natural product chemotherapeutic drugs is conferred on cancer cells by expression of the MDR1 gene, which encodes the 170-kDa multidrug transporter known as P glycoprotein. The P glycoprotein-mediated efflux of toxic chemotherapeutic drugs can be reversed by agents such as verapamil, which is a substrate for the multidrug transporter and appears to be a competitive inhibitor of...

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PMID: 1681415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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