Fluorescent verapamil derivative for monitoring activity of the multidrug transporter.

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Article

Fluorescent verapamil derivative for monitoring activity of the multidrug transporter.

Molecular pharmacology - 1 Oct 1991

Lelong I H, Guzikowski A P, Haugland R P, Pastan I, Gottesman M M, Willingham M C

Abstract excerpt

Multidrug resistance to amphipathic natural product chemotherapeutic drugs is conferred on cancer cells by expression of the MDR1 gene, which encodes the 170-kDa multidrug transporter known as P glycoprotein. The P glycoprotein-mediated efflux of toxic chemotherapeutic drugs can be reversed by ag...

Topics

3T3 Cells
ATP Binding Cassette Transporter, Subfamily B, Member 1
Animals
Cell Survival
Drug Resistance
Fluorescent Dyes
Humans
KB Cells
Lysosomes
Membrane Glycoproteins
Mice
Microscopy, Fluorescence
Phenotype
Tumor Cells, Cultured
Verapamil

Source

Open in PubMed

Identifiers

PMID: 1681415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1681415-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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