Article
Trimers of N-alkylglycines are potent modulators of the multidrug resistance phenotype.
The Journal of pharmacology and experimental therapeutics - 1 Apr 2005
Abad-Merin Maria J, Cortés Nuria, Masip Isabel, Pérez-Payá Enrique, Ferragut José A, Messeguer Angel, Ferrer-Montiel Antonio
Abstract excerpt
The multidrug resistance (MDR) phenotype is considered a major cause of the failure of cancer chemotherapy. The acquisition of MDR is usually mediated by the overexpression of drug efflux pumps such as glycoprotein P (P-gp) or multidrug resistance-related protein 1 (MRP1). Thus, the identification, validation, and development of compounds that mitigate the MDR phenotype by modulating the activity of these...
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