Article
A structurally flexible and antigenically variable N-terminal domain of the hepatitis C virus E2/NS1 protein: implication for an escape from antibody.
Virology - 1 Jul 1993
Taniguchi S, Okamoto H, Sakamoto M, Kojima M, Tsuda F, Tanaka T, Munekata E, Muchmore E E, Peterson D A, Mishiro S
Abstract excerpt
Hepatitis C virus persists in most infected hosts, and causes chronic hepatitis, liver cirrhosis, and/or hepatocellular carcinoma in humans. During the infection the RNA genome of hepatitis C virus undergoes frequent missense mutations at one or two "hypervariable" regions within a presumptive en...
Topics
- Amino Acid Sequence
- Animals
- Antigenic Variation
- Antigens, Viral
- Epitopes
- Hepacivirus
- Hepatitis Antibodies
- Hepatitis C
- Hepatitis C Antibodies
- Hepatitis C Antigens
- Humans
- Molecular Sequence Data
- Mutation
- Pan troglodytes
- Protein Structure, Secondary