Article
Radiation-induced mutations in the spleen and brain of lacZ transgenic mice.
International journal of radiation biology - 1 Mar 2000
Nakamura S, Ikehata H, Komura J, Hosoi Y, Inoue H, Gondo Y, Yamamoto K, Ichimasa Y, Ono T
Abstract excerpt
PURPOSE: To study the dose-response and molecular nature of radiation-induced mutations in the spleen and brain of lacZ transgenic mice. MATERIALS AND METHODS: Line 60 transgenic mice containing the bacterial lacZ gene in a plasmid background were used. Mutants were selected using phenyl-beta-D-galactoside. The nature of mutants was determined by sequencing DNAs of mutant lacZ genes found in control and...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Brain
- DNA Mutational Analysis
- Dose-Response Relationship, Radiation
- Lac Operon
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Organ Specificity
- Sequence Deletion
- Spleen
- Whole-Body Irradiation
- X-Rays