Article
Radiation-induced mutations in the spleen and brain of lacZ transgenic mice.
International journal of radiation biology - 1 Mar 2000
Nakamura S, Ikehata H, Komura J, Hosoi Y, Inoue H, Gondo Y, Yamamoto K, Ichimasa Y, Ono T
Abstract excerpt
PURPOSE: To study the dose-response and molecular nature of radiation-induced mutations in the spleen and brain of lacZ transgenic mice. MATERIALS AND METHODS: Line 60 transgenic mice containing the bacterial lacZ gene in a plasmid background were used. Mutants were selected using phenyl-beta-D-galactoside. The nature of mutants was determined by sequencing DNAs of mutant lacZ genes found in control and...
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