Article
Cellular and karyotypic characterization of two doxorubicin resistant cell lines isolated from the same parental human leukemia cell line.
International journal of cancer - 15 May 1994
Zalcberg J R, Hu X F, Wall D M, Mirski S, Cole S, Nadalin G, De Luise M, Parkin J D, Vrazas V, Campbell L
Abstract excerpt
Separate mechanisms underlying the multidrug resistant (MDR) phenotype were identified in 2 independent approaches to select tumour cells resistant to low concentrations of doxorubicin (Dox) from the sensitive T cell leukemia cell line CCRF-CEM. The CEM/A7 cell line was selected at an initial con...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antibodies
- Antineoplastic Agents
- Carrier Proteins
- DNA Topoisomerases, Type II
- Doxorubicin
- Drug Resistance
- Flow Cytometry
- Gene Amplification
- Humans
- Immunoblotting
- Karyotyping
- Leukemia
- Membrane Glycoproteins