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Article

Novel selection and genetic characterisation of an etoposide-resistant human leukaemic CCRF-CEM cell line.

British journal of cancer - 1 Mar 1993

Patel S, Fisher L M

Abstract excerpt

We have studied the genetic alterations acquired during selection of a cloned human leukaemic cell line (CEM/VP-1) that is 15-fold more resistant to the anticancer topoisomerase II-inhibitor etoposide than parental CCRF-CEM cells. CEM/VP-1 cells exhibit an 'atypical MDR' phenotype: cross resistance to other topo II inhibitors (but not Vinca alkaloids) and expression of a drug-resistant topo II activity....

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Identifiers

PMID: 8382508
DOI: 10.1038/bjc.1993.87
PMCID: PMC1968246

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Source receipt: pubmed, retrieved 7 Sept 2026.

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