Novel selection and genetic characterisation of an etoposide-resistant human leukaemic CCRF-CEM cell line.

doi:10.1038/bjc.1993.87

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Article

Novel selection and genetic characterisation of an etoposide-resistant human leukaemic CCRF-CEM cell line.

British journal of cancer - 1 Mar 1993

Patel S, Fisher L M

Abstract excerpt

We have studied the genetic alterations acquired during selection of a cloned human leukaemic cell line (CEM/VP-1) that is 15-fold more resistant to the anticancer topoisomerase II-inhibitor etoposide than parental CCRF-CEM cells. CEM/VP-1 cells exhibit an 'atypical MDR' phenotype: cross resistan...

Topics

Base Sequence
Chromosome Banding
Chromosomes, Human, Pair 20
Chromosomes, Human, Pair 3
Codon
DNA Topoisomerases, Type II
DNA, Neoplasm
Drug Resistance
Etoposide
Humans
Karyotyping
Leukemia
Molecular Sequence Data
Mutation
Phenotype
Polymerase Chain Reaction
Sequence Analysis, DNA
Tumor Cells, Cultured

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Identifiers

PMID: 8382508
DOI: 10.1038/bjc.1993.87
PMCID: PMC1968246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8382508-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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