Article
Inheritance of chromosome 7 is associated with a drug-resistant phenotype in somatic cell hybrids.
British journal of cancer - 1 Jan 1996
de Silva M, Kantharidis P, Wall D M, Campbell L, Vrazas V, Nadalin G, Kaczmarczyk S J, Hu X F, Parkin J D, Zalcberg J R
Abstract excerpt
A major form of drug resistance in tumour cells known as classical multidrug resistance (MDR) is associated with the overexpression of the mdr1 gene product, the membrane protein P-glycoprotein (P-gp), which acts as an energy-dependent drug efflux pump. In this study the inheritance of P-gp expression was examined using hybrids formed after somatic cell fusion between a drug-sensitive human T-cell leukaemia cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.