Article
Inheritance of chromosome 7 is associated with a drug-resistant phenotype in somatic cell hybrids.
British journal of cancer - 1 Jan 1996
de Silva M, Kantharidis P, Wall D M, Campbell L, Vrazas V, Nadalin G, Kaczmarczyk S J, Hu X F, Parkin J D, Zalcberg J R
Abstract excerpt
A major form of drug resistance in tumour cells known as classical multidrug resistance (MDR) is associated with the overexpression of the mdr1 gene product, the membrane protein P-glycoprotein (P-gp), which acts as an energy-dependent drug efflux pump. In this study the inheritance of P-gp expre...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antibiotics, Antineoplastic
- Antibodies, Monoclonal
- Base Sequence
- Chromosome Aberrations
- Chromosomes, Human, Pair 7
- DNA Primers
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Epirubicin
- Humans
- Hybrid Cells