Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene,MDR1/P-glycoprotein, in drug-selected cell lines and patients with drug refractory ALL

Abstract excerpt

Drug resistance, both primary and acquired, is a major obstacle to advances in cancer chemotherapy. In vitro, multidrug resistance can be mediated by P-glycoprotein (PGY1), a cell surface phosphoglycoprotein that acts to efflux natural products from cells. PGY1 is encoded by the MDR1 gene located at 7q21.1. Overexpression of MDR1 has been demonstrated in many cancers, both in patient tumors and in cell lines...

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