Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of a multidrug-resistant chronic myeloid leukemia cell line presenting multiple resistance mechanisms.

Molecular and cellular biochemistry - 1 Nov 2013

Daflon-Yunes Nathalia, Pinto-Silva Flavio Eduardo, Vidal Raphael Silveira, Novis Bruna Fortunato, Berguetti Tandressa, Lopes Raphael Rodrigues Soares, Polycarpo Carla, Rumjanek Vivian M

Abstract excerpt

The multidrug-resistant (MDR) phenotype is multifactorial, and cell lines presenting multiple resistance mechanisms might be good models to understand the importance of the various pathways involved. The present work characterized a MDR chronic myeloid leukemia cell line, derived from K562 through a selective process using daunorubicin. This MDR cell line was shown to be resistant to vincristine, daunorubicin,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation, T-Lymphocyte
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple

Share to fas Receptor

Share to Interleukin-8

Share to Lectins, C-Type

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Multidrug Resistance-Associated Proteins

Source

Identifiers

PMID: 23877223
DOI: 10.1007/s11010-013-1761-0

Genes

ABCB1
ABCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a multidrug-resistant chronic myeloid leukemia cell line presenting multiple resistance mechanisms.PMID 23877223Read ↗

Multidrug resistance in chronic myeloid leukaemia: how much can we learn from MDR–CML cell lines?Semantic proximity Read ↗

The Genomic Stability at the Coding Regions of the Multidrug Transporter Gene <i>ABCB1</i> : Insights into the Development of Alternative Drug Resistance Mechanisms in Human Leukemia CellsSemantic proximity Read ↗

Multidrug resistance in tumour cells: characterization of the multidrug resistant cell line K562-Lucena 1.Semantic proximity Read ↗

Multidrug resistance in hematological malignancy.Semantic proximity Read ↗

ABCA1 is associated with the development of acquired chemotherapy resistance and predicts poor ovarian cancer outcomeSemantic proximity Read ↗

Development of imatinib and dasatinib resistance: dynamics of expression of drug transportersABCB1, ABCC1, ABCG2, MVP, and SLC22A1Semantic proximity Read ↗

Mechanisms of cellular resistance to imatinib in human chronic myeloid leukemia cellsSemantic proximity Read ↗

The acquisition order of leukemic drug resistance mutations is directed by the selective fitness associated with each resistance mechanism.Semantic proximity Read ↗

Drug resistance mechanisms in acute leukemia.Semantic proximity Read ↗

[Resistance to chemotherapy: current progress].Semantic proximity Read ↗

Evaluation of multidrug resistant phenotype by flow cytometry with monoclonal antibodies and functional tests.Semantic proximity Read ↗

Overcome Resistance in Doxorubicin-Adapted Hodgkin Lymphoma Cells With Acquired Multidrug Resistance and Improved Immunosuppressive AbilitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.