Article
Multiple sclerosis: Brain-infiltrating CD8 <sup>+</sup> T cells persist as clonal expansions in the cerebrospinal fluid and blood
17 Feb 2004
Abstract excerpt
We surveyed the T cell receptor repertoire in three separate compartments (brain, cerebrospinal fluid, and blood) of two multiple sclerosis patients who initially had diagnostic brain biopsies to clarify their unusual clinical presentation but were subsequently confirmed to have typical multiple sclerosis. One of the brain biopsy specimens had been previously investigated by microdissection and single-cell PCR to...