A complex role of herpes viruses in the disease process of multiple sclerosis.

doi:10.1371/journal.pone.0105434

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A complex role of herpes viruses in the disease process of multiple sclerosis.

PloS one - 1 Jan 2014

Wuest Simone C, Mexhitaj Ina, Chai Noo Ri, Romm Elena, Scheffel Joerg, Xu Biying, Lane Kelly, Wu Tianxia, Bielekova Bibiana

Abstract excerpt

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS). Neither the antigenic target(s) nor the cell population(s) responsible for CNS tissue destruction in MS have been fully defined. The objective of this study was to simultaneously determine the antigen (Ag)-specificity and phenotype of un-manipulated intrathecal CD4+ and CD8+ T cells of patients with relapsing-remitting...

Topics

Adult
Aged
Antibodies, Monoclonal, Humanized
Antigens, Viral
Autoantigens
Case-Control Studies
Daclizumab
Epitopes, T-Lymphocyte
Female
Herpesviridae
Herpesviridae Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunoglobulin G

Immunophenotyping

Immunosuppressive Agents

Lymphocyte Activation

Male

Middle Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 25148387
DOI: 10.1371/journal.pone.0105434
PMCID: PMC4141762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A complex role of herpes viruses in the disease process of multiple sclerosis.PMID 25148387Read ↗

Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patientsSemantic proximity Read ↗

The CD8 T Cell-Epstein-Barr Virus-B Cell Trialogue: A Central Issue in Multiple Sclerosis PathogenesisSemantic proximity Read ↗

The Enigmatic Role of Viruses in Multiple Sclerosis: Molecular Mimicry or Disturbed Immune Surveillance?Semantic proximity Read ↗

Antigen-resolved remodeling of EBV-specific CD8⁺ T cell immunity in multiple sclerosisSemantic proximity Read ↗

Cumulative Roles for Epstein-Barr Virus, Human Endogenous Retroviruses, and Human Herpes Virus-6 in Driving an Inflammatory Cascade Underlying MS Pathogenesis.Semantic proximity Read ↗

The immunology of multiple sclerosis.Semantic proximity Read ↗

Which immune cells matter? The immunopathogenesis of multiple sclerosis.Semantic proximity Read ↗

Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosisSemantic proximity Read ↗

Single-cell analysis suggests coordinated immune-cell redistribution between blood and cerebrospinal fluid in early multiple sclerosisSemantic proximity Read ↗

Study of Herpesvirus saimiri immortalization of gammadelta T cells derived from peripheral blood and CSF of multiple sclerosis patients.Semantic proximity Read ↗

Intrathecally expanded GZMK+/GZMH+ CD8 T cells targeting EBV antigens may reduce severity of Multiple SclerosisSemantic proximity Read ↗

The compartmentalized inflammatory response in the multiple sclerosis brain is composed of tissue-resident CD8+ T lymphocytes and B cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.