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Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis

1 Sept 2022

Abstract excerpt

Epstein-Barr virus (EBV) infection precedes multiple sclerosis (MS) pathology and cross-reactive antibodies might link EBV infection to CNS autoimmunity. As an altered anti-EBV T cell reaction was suggested in MS, we queried peripheral blood T cell receptor β chain (TCRβ) repertoires of 1,395 MS patients, 887 controls, and 35 monozygotic, MS-discordant twin pairs for multimer-confirmed, viral antigen-specific...

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PMID: 36048016
DOI: 10.1084/jem.20220650

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