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Article

Upregulation of lineage specific receptors and ligands in multipotential progenitor cells is part of an endogenous program of differentiation.

Growth factors (Chur, Switzerland) - 1 Jan 1993

Just U, Friel J, Heberlein C, Tamura T, Baccarini M, Tessmer U, Klingler K, Ostertag W

Abstract excerpt

Multipotent hematopoietic progenitor cell lines (FDCP-Mix) infected with a retroviral vector expressing the GM-CSF gene show functional downregulation of the GM-CSF receptor when maintained in IL-3 and activation of the receptor resulting in synchronous differentiation into mature granulocytes and macrophages on withdrawal of IL-3. This system has now been used to investigate whether or not receptors for some of...

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Identifiers

PMID: 7511905
DOI: 10.3109/08977199308991589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Upregulation of lineage specific receptors and ligands in multipotential progenitor cells is part of an endogenous program of differentiation.PMID 7511905Read ↗

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