Article
Upregulation of lineage specific receptors and ligands in multipotential progenitor cells is part of an endogenous program of differentiation.
Growth factors (Chur, Switzerland) - 1 Jan 1993
Just U, Friel J, Heberlein C, Tamura T, Baccarini M, Tessmer U, Klingler K, Ostertag W
Abstract excerpt
Multipotent hematopoietic progenitor cell lines (FDCP-Mix) infected with a retroviral vector expressing the GM-CSF gene show functional downregulation of the GM-CSF receptor when maintained in IL-3 and activation of the receptor resulting in synchronous differentiation into mature granulocytes an...
Topics
- Animals
- Bone Marrow Cells
- Cytokines
- Erythropoietin
- Granulocyte Colony-Stimulating Factor
- Granulocyte-Macrophage Colony-Stimulating Factor
- Hematopoiesis
- Hematopoietic Stem Cells
- Ligands
- Macrophage Colony-Stimulating Factor
- Mutation
- Polymerase Chain Reaction
- RNA, Messenger
- Receptors, Cytokine