Article
Expression of Epstein-Barr virus latent membrane protein influences self-renewal and differentiation in a multipotential murine haemopoietic 'stem cell' line.
The Journal of general virology - 1 Feb 1993
Fairbairn L J, Stewart J P, Hampson I N, Arrand J R, Dexter T M
Abstract excerpt
The product encoded by the latent membrane protein (LMP) gene of Epstein-Barr virus (EBV) has been implicated as a transforming protein by a number of studies. We have examined the effects of LMP expression in FDCP-mix cells, a growth factor-dependent multipotential murine 'stem cell' line. Our studies show that LMP reduces the generation of clonogenic cells and leads to the production of cells expressing a...
Topics
- Animals
- Antigens, Viral
- Cell Differentiation
- Cell Line, Transformed
- Cell Transformation, Viral
- Hematopoietic Stem Cells
- Herpesvirus 4, Human
- Membrane Proteins
- Phenotype
- Viral Matrix Proteins