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Article

Macrophage colony stimulating factor down-regulates MCSF-receptor expression and entry of progenitors into the osteoclast lineage.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 1997

Fan X, Biskobing D M, Fan D, Hofstetter W, Rubin J

Abstract excerpt

Macrophage colony-stimulating factor (MCSF), although necessary for entry of precursors into the early preosteoclast pathway, inhibits osteoclastogenesis at high doses. To clarify the relationship between MCSF and osteoclast formation, we investigated the effect of exogenous MCSF in murine bone marrow culture. Precursor proliferation and the expression of MCSF-receptor were examined after 4 days of culture in the...

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PMID: 9286754
DOI: 10.1359/jbmr.1997.12.9.1387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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