Macrophage colony stimulating factor down-regulates MCSF-receptor expression and entry of progenitors into the osteoclast lineage.

doi:10.1359/jbmr.1997.12.9.1387

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Article

Macrophage colony stimulating factor down-regulates MCSF-receptor expression and entry of progenitors into the osteoclast lineage.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 1997

Fan X, Biskobing D M, Fan D, Hofstetter W, Rubin J

Abstract excerpt

Macrophage colony-stimulating factor (MCSF), although necessary for entry of precursors into the early preosteoclast pathway, inhibits osteoclastogenesis at high doses. To clarify the relationship between MCSF and osteoclast formation, we investigated the effect of exogenous MCSF in murine bone m...

Topics

Animals
Bone Marrow Cells
Cells, Cultured
Down-Regulation
Macrophage Colony-Stimulating Factor
Mice
Osteoclasts
Phenotype
Receptor, Macrophage Colony-Stimulating Factor
Stem Cells
Surface Properties

Source

Open in PubMed

Identifiers

PMID: 9286754
DOI: 10.1359/jbmr.1997.12.9.1387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9286754-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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