Article
IL-3 and ribavirin induce differentiation and growth suppression during long-term treatment of a megakaryocytic leukemia cell line.
Journal of cellular physiology - 1 Dec 1995
Majumdar A, Kerby S, Mullikin B, Beckstead J H, Stenberg P E, Seidman M M
Abstract excerpt
Differentiation of the megakaryocytic leukemia cells, CMK, was induced by long-term (12 day) treatment with the combination of IL-3 and the nucleoside analogue ribavirin (RV), which reduces cellular GTP levels. In a previous report we demonstrated the induction of early messages and antigens, as well as the formation of giant polyploid cells in the cultures (Majumdar et al., 1994, J. Cell. Physiol., 160:29-39)....
Topics
- Cell Adhesion Molecules
- Cell Differentiation
- Cell Division
- Growth Inhibitors
- Guanosine
- Humans
- Interleukin-3
- Leukemia, Megakaryoblastic, Acute
- Megakaryocytes
- Membrane Glycoproteins