Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain.

The Journal of biological chemistry - 14 Apr 1995

O'Toole T E, Ylanne J, Culley B M

Abstract excerpt

The ligand binding affinities of the integrins are regulated through their cytoplasmic domains. To identify specific residues that are involved in this process, we have generated mutants in the beta 1 and beta 3 tails and coexpressed them in Chinese hamster ovary cells with constitutively active alpha subunits. These alpha subunits are chimera of extra-cellular and transmembrane alpha IIb joined to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cricetinae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Oligodeoxyribonucleotides

Share to Protein Binding

Share to Signal Transduction

Source

Identifiers

PMID: 7721755
DOI: 10.1074/jbc.270.15.8553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain.PMID 7721755Read ↗

The novel S527F mutation in the integrin beta3 chain induces a high affinity alphaIIbbeta3 receptor by hindering adoption of the bent conformation.Semantic proximity Read ↗

Internalization of the alpha 5 beta 1 integrin does not depend on "NPXY" signals.Semantic proximity Read ↗

NPXY motifs control the recruitment of the alpha5beta1 integrin in focal adhesions independently of the association of talin with the beta1 chain.Semantic proximity Read ↗

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.Semantic proximity Read ↗

Breaking the Integrin HingeSemantic proximity Read ↗

Role of the transmembrane and cytoplasmic domains in the assembly and surface exposure of the platelet integrin GPIIb/IIIa.Semantic proximity Read ↗

alpha-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation.Semantic proximity Read ↗

Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin.Semantic proximity Read ↗

Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association.Semantic proximity Read ↗

Isolated integrin beta3 subunit cytoplasmic domains require membrane anchorage and the NPXY motif to recruit to adhesion complexes but do not discriminate between beta1- and beta3-positive complexes.Semantic proximity Read ↗

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cellsSemantic proximity Read ↗

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.