Article
Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain.
The Journal of biological chemistry - 14 Apr 1995
O'Toole T E, Ylanne J, Culley B M
Abstract excerpt
The ligand binding affinities of the integrins are regulated through their cytoplasmic domains. To identify specific residues that are involved in this process, we have generated mutants in the beta 1 and beta 3 tails and coexpressed them in Chinese hamster ovary cells with constitutively active...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- Cytoplasm
- Integrins
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Protein Binding
- Signal Transduction