Article
Fc receptor endocytosis is controlled by a cytoplasmic domain determinant that actively prevents coated pit localization.
The Journal of cell biology - 1 Feb 1992
Miettinen H M, Matter K, Hunziker W, Rose J K, Mellman I
Abstract excerpt
Macrophages and B-lymphocytes express two major isoforms of Fc receptor (FcRII-B2 and FcRII-B1) that exhibit distinct capacities for endocytosis. This difference in function reflects the presence of an in-frame insertion of 47 amino acids in the cytoplasmic domain of the lymphocyte isoform (FcRII...
Topics
- Actins
- Amino Acid Sequence
- Animals
- Antigen-Antibody Complex
- Base Sequence
- CHO Cells
- Cell Line
- Coated Pits, Cell-Membrane
- Cricetinae
- Cytoplasm
- Cytoskeleton
- Endocytosis
- Immunohistochemistry
- Microscopy, Immunoelectron
- Molecular Sequence Data
- Mutation
- Receptors, Fc
- Transfection