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α <sub>5</sub> β <sub>1</sub> -Integrin controls ebolavirus entry by regulating endosomal cathepsins

28 Apr 2009

Abstract excerpt

Integrins are involved in the binding and internalization of both enveloped and nonenveloped viruses. By using 3 distinct cell systems-CHO cells lacking expression of alpha(5)beta(1)-integrin, HeLa cells treated with siRNA to alpha(5)-integrin, and mouse beta(1)-integrin knockout fibroblasts, we show that alpha(5)beta(1)-integrin is required for efficient infection by pseudovirions bearing the ebolavirus...

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Identifiers

PMID: 19416892
DOI: 10.1073/pnas.0807578106

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