Article
NPXY motifs control the recruitment of the alpha5beta1 integrin in focal adhesions independently of the association of talin with the beta1 chain.
Journal of cell science - 1 Jun 1997
Vignoud L, Albigès-Rizo C, Frachet P, Block M R
Abstract excerpt
With the exception of the divergent beta4 and beta8 chains, the integrin beta subunit cytoplasmic domains are short and highly conserved sequences. Consensus motifs are found among the different cytoplasmic beta chains. Experiments using chimeric receptors demonstrated that the 47 amino acids of the beta1 subunit cytoplasmic domain contain sufficient information to target integrins to adhesion plaques. Three...
Topics
- Amino Acid Sequence
- Animals
- CHO Cells
- Cell Adhesion
- Cricetinae
- Fibronectins
- Fluorescent Antibody Technique, Indirect
- Humans
- Integrin beta1
- Microscopy, Electron
- Molecular Sequence Data
- Mutation
- Receptors, Fibronectin
- Talin
- Transfection