Article
Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.
Proceedings of the National Academy of Sciences of the United States of America - 15 Mar 1994
Wu J, Zhou T, Zhang J, He J, Gause W C, Mountz J D
Abstract excerpt
MRL-lpr/lpr mice develop a generalized autoimmune disease which includes increased autoantibody production, glomerulonephritis, and development of lymphadenopathy. The lpr genetic defect has been identified as a mutation in the Fas apoptosis gene that results in low expression of Fas mRNA. To determine the significance of the lpr mutation and T cells in the development of the autoimmune disease, we constructed...
Topics
- Animals
- Antigens, Surface
- Apoptosis
- Autoimmune Diseases
- Base Sequence
- Blotting, Northern
- DNA
- Enhancer Elements, Genetic
- Fluorescent Antibody Technique
- Humans