Mutations in the Fas antigen gene in lpr mice.

doi:10.1006/smim.1994.1002

Back to search

Article

Mutations in the Fas antigen gene in lpr mice.

Seminars in immunology - 1 Feb 1994

Nagata S

Abstract excerpt

The Fas antigen is a cell surface protein belonging to the tumor necrosis factor/nerve growth factor receptor family and it mediates apoptosis. The Fas antigen gene is the structural gene for the mouse mutation, lpr (lymphoproliferation). In one allele of lpr, an early transposable element (a mou...

Topics

Animals
Antigens, Surface
Apoptosis
Humans
Lymphoproliferative Disorders
Mice
Mice, Mutant Strains
Mutation
Signal Transduction
fas Receptor

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.