Article
The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn.
The Journal of experimental medicine - 1 Aug 1993
Chu J L, Drappa J, Parnassa A, Elkon K B
Abstract excerpt
Fas is a cell surface protein of the tumor necrosis factor receptor, nerve growth factor receptor, CD40 family, and is involved in the control of lymphocyte apoptosis. A mutation in the Fas gene in MRL/lpr mice results in massive lymphoproliferation (lpr) and accelerated autoimmunity. To further...
Topics
- Animals
- Antigens, Surface
- Autoimmune Diseases
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- DNA
- DNA Transposable Elements
- Lymphoid Tissue
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- RNA, Messenger
- Sequence Homology, Nucleic Acid
- fas Receptor