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Article

Minimal sequence requirements of a functional human immunodeficiency virus type 1 primer binding site.

Journal of virology - 1 Mar 1994

Wakefield J K, Rhim H, Morrow C D

Abstract excerpt

The initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription occurs by the extension of a tRNA(3Lys) primer bound near the 5' end of the genomic RNA at a position termed the primer binding site (PBS). The PBS is an 18-nucleotide sequence of the HIV-1 genome which is complementary to the 3'-terminal 18 nucleotides of the tRNA(3Lys). To investigate the sequence specificity of the interaction...

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Identifiers

PMID: 7508999
DOI: 10.1128/JVI.68.3.1605-1614.1994
PMCID: PMC236618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Minimal sequence requirements of a functional human immunodeficiency virus type 1 primer binding site.PMID 7508999Read ↗

Mutations within the primer binding site of the human immunodeficiency virus type 1 define sequence requirements essential for reverse transcription.Semantic proximity Read ↗

Construction of a type 1 human immunodeficiency virus that maintains a primer binding site complementary to tRNA(His).Semantic proximity Read ↗

Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replicationSemantic proximity Read ↗

Deletions in the tRNA(Lys) primer-binding site of human immunodeficiency virus type 1 identify essential regions for reverse transcriptionSemantic proximity Read ↗

Mutations in both the U5 region and the primer-binding site influence the selection of the tRNA used for the initiation of HIV-1 reverse transcription.Semantic proximity Read ↗

Identification of sequences downstream of the primer binding site that are important for efficient replication of human immunodeficiency virus type 1.Semantic proximity Read ↗

Forced selection of tRNA(Glu) reveals the importance of two adenosine-rich RNA loops within the U5-PBS for SIV(smmPBj) replication.Semantic proximity Read ↗

Reduced replication of human immunodeficiency virus type 1 mutants that use reverse transcription primers other than the natural tRNA(3Lys).Semantic proximity Read ↗

The tRNA primer activation signal in the human immunodeficiency virus type 1 genome is important for initiation and processive elongation of reverse transcription.Semantic proximity Read ↗

Essential regions of the tRNA primer required for HIV-1 infectivity.Semantic proximity Read ↗

A structured RNA motif is involved in correct placement of the tRNA(3)(Lys) primer onto the human immunodeficiency virus genome.Semantic proximity Read ↗

Nucleotide substitutions within U5 are critical for efficient reverse transcription of human immunodeficiency virus type 1 with a primer binding site complementary to tRNA(His).Semantic proximity Read ↗

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