Article
Minimal sequence requirements of a functional human immunodeficiency virus type 1 primer binding site.
Journal of virology - 1 Mar 1994
Wakefield J K, Rhim H, Morrow C D
Abstract excerpt
The initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription occurs by the extension of a tRNA(3Lys) primer bound near the 5' end of the genomic RNA at a position termed the primer binding site (PBS). The PBS is an 18-nucleotide sequence of the HIV-1 genome which is complementary to the 3'-terminal 18 nucleotides of the tRNA(3Lys). To investigate the sequence specificity of the interaction...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cells, Cultured
- DNA Mutational Analysis
- Genome, Viral
- HIV Reverse Transcriptase
- HIV-1
- Molecular Sequence Data
- Mutation
- Proviruses