Article
Nucleotide substitutions within U5 are critical for efficient reverse transcription of human immunodeficiency virus type 1 with a primer binding site complementary to tRNA(His).
Journal of virology - 1 Sept 1997
Li Y, Zhang Z, Wakefield J K, Kang S M, Morrow C D
Abstract excerpt
Sequence analysis of integrated proviruses of human immunodeficiency virus type 1 (HIV-1) which utilize tRNA(His) to initiate reverse transcription [virus derived from pHXB2(His-AC-TGT)] revealed five additional nucleotide substitutions in the U5 and primer binding site (PBS) regions (ATGAC for C...
Topics
- Animals
- Base Sequence
- Binding Sites
- COS Cells
- DNA Primers
- DNA, Viral
- Genetic Complementation Test
- HIV Core Protein p24
- HIV-1
- Humans
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Proviruses
- RNA, Transfer, His